FBXO41
Gene Information
- Official Symbol: FBXO41
- Official Name: F-box protein 41
- Aliases and Previous Symbols: N/A
- Entrez ID: 150726
- UniProt: Q8TF61
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014].
- UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3024
- Expression level (log2 read counts): 7.11
FBXO41 Expression in NALM6 Cells: 7.11
