FGF21
Gene Information
- Official Symbol: FGF21
- Official Name: fibroblast growth factor 21
- Aliases and Previous Symbols: N/A
- Entrez ID: 26291
- UniProt: Q9NSA1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016].
- UniProt Summary: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}.
Pfam Domains GO Terms
Pfam Domains
| FGF |
GO Terms
| response to methionine |
| positive regulation of low-density lipoprotein particle receptor biosynthetic process |
| positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| positive regulation of triglyceride catabolic process |
| endothelial cell apoptotic process |
| regulation of low-density lipoprotein particle receptor biosynthetic process |
| regulation of low-density lipoprotein particle clearance |
| regulation of triglyceride catabolic process |
| positive regulation of receptor biosynthetic process |
| cellular response to low-density lipoprotein particle stimulus |
| regulation of lipoprotein particle clearance |
| positive regulation of triglyceride metabolic process |
| fibroblast growth factor receptor binding |
| regulation of receptor biosynthetic process |
| positive regulation of lipid catabolic process |
| cellular response to glucagon stimulus |
| response to lipoprotein particle |
| epithelial cell apoptotic process |
| cellular response to lipoprotein particle stimulus |
| negative regulation of endothelial cell apoptotic process |
| regulation of triglyceride metabolic process |
| response to glucagon |
| positive regulation of glucose import |
| negative regulation of epithelial cell apoptotic process |
| positive regulation of glucose transmembrane transport |
| regulation of endothelial cell apoptotic process |
| regulation of lipid catabolic process |
| regulation of glucose import |
| response to activity |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| regulation of glucose transmembrane transport |
| regulation of epithelial cell apoptotic process |
| fibroblast growth factor receptor signaling pathway |
| cellular response to carbohydrate stimulus |
| cell |
| cellular glucose homeostasis |
| positive regulation of cold-induced thermogenesis |
| endoplasmic reticulum unfolded protein response |
| cellular response to fibroblast growth factor stimulus |
| response to amino acid |
| response to fibroblast growth factor |
| cellular response to unfolded protein |
| response to glucose |
| positive regulation of lipid metabolic process |
| response to hexose |
| regulation of cold-induced thermogenesis |
| response to monosaccharide |
| cellular response to topologically incorrect protein |
| response to unfolded protein |
| growth factor activity |
| response to carbohydrate |
| glucose homeostasis |
| carbohydrate homeostasis |
| response to topologically incorrect protein |
| positive regulation of transmembrane transport |
| negative regulation of neuron death |
| positive regulation of ERK1 and ERK2 cascade |
| response to endoplasmic reticulum stress |
| cellular response to peptide hormone stimulus |
| regulation of ERK1 and ERK2 cascade |
| regulation of neuron death |
| cellular response to peptide |
| response to acid chemical |
| positive regulation of cellular catabolic process |
| response to peptide hormone |
| regulation of lipid metabolic process |
| cellular response to drug |
| positive regulation of catabolic process |
| response to peptide |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to extracellular stimulus |
| response to growth factor |
| positive regulation of MAPK cascade |
| regulation of transmembrane transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| enzyme linked receptor protein signaling pathway |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| apoptotic process |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| cell death |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| VE-822 0.04μM R06 exp300 | 1.88 |
| Citral 50μM R06 exp274 | 2.35 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5838
- Expression level (log2 read counts): -6.02
Expression Distribution
FGF21 Expression in NALM6 Cells: -6.02
