FIGN
Gene Information
- Official Symbol: FIGN
- Official Name: fidgetin, microtubule severing factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 55137
- UniProt: Q5HY92
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. {ECO:0000269|PubMed:22672901}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6429
- Expression level (log2 read counts): -0.23
FIGN Expression in NALM6 Cells: -0.23
