FREM1
Gene Information
- Official Symbol: FREM1
- Official Name: FRAS1 related extracellular matrix 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 158326
- UniProt: Q5H8C1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011].
- UniProt Summary: Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6690
- Expression level (log2 read counts): -6.6
FREM1 Expression in NALM6 Cells: -6.6
