FSTL4
Gene Information
- Official Symbol: FSTL4
- Official Name: follistatin like 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 23105
- UniProt: Q6MZW2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Kazal 2 |
| I-set |
| Kazal 1 |
| ig |
GO Terms
| negative regulation of brain-derived neurotrophic factor receptor signaling pathway |
| regulation of brain-derived neurotrophic factor receptor signaling pathway |
| brain-derived neurotrophic factor binding |
| negative regulation of collateral sprouting |
| negative regulation of dendritic spine development |
| regulation of collateral sprouting |
| negative regulation of dendrite development |
| negative regulation of axonogenesis |
| regulation of dendritic spine development |
| secretory granule |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| regulation of dendrite development |
| negative regulation of neuron projection development |
| regulation of cell size |
| negative regulation of cell projection organization |
| negative regulation of cell growth |
| regulation of axonogenesis |
| negative regulation of neuron differentiation |
| negative regulation of growth |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| regulation of developmental growth |
| negative regulation of cell development |
| regulation of cellular component size |
| regulation of cell growth |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| calcium ion binding |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of anatomical structure morphogenesis |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| generation of neurons |
| negative regulation of response to stimulus |
| neurogenesis |
| regulation of cell differentiation |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lapatinib 5μM R01 exp47 | -1.94 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5748
- Expression level (log2 read counts): 1.55
Expression Distribution
FSTL4 Expression in NALM6 Cells: 1.55
