FYN
Gene Information
- Official Symbol: FYN
- Official Name: FYN proto-oncogene, Src family tyrosine kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 2534
- UniProt: P06241
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. {ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| SH2 |
| Pkinase Tyr |
| SH3 1 |
| Pkinase |
GO Terms
| response to singlet oxygen |
| cellular response to glycine |
| response to glycine |
| CD8 receptor binding |
| negative regulation of dendritic spine maintenance |
| growth factor receptor binding |
| regulation of calcium ion import across plasma membrane |
| negative regulation of hydrogen peroxide biosynthetic process |
| type 5 metabotropic glutamate receptor binding |
| cellular response to L-glutamate |
| activated T cell proliferation |
| T cell receptor binding |
| positive regulation of non-membrane spanning protein tyrosine kinase activity |
| negative regulation of cofactor metabolic process |
| CD4 receptor binding |
| negative regulation of hydrogen peroxide metabolic process |
| regulation of hydrogen peroxide biosynthetic process |
| regulation of non-membrane spanning protein tyrosine kinase activity |
| peptide hormone receptor binding |
| glial cell projection |
| dendritic spine maintenance |
| response to L-glutamate |
| regulation of dendritic spine maintenance |
| detection of mechanical stimulus involved in sensory perception of pain |
| perinuclear endoplasmic reticulum |
| postsynaptic density, intracellular component |
| cellular response to platelet-derived growth factor stimulus |
| regulation of hydrogen peroxide metabolic process |
| phosphatidylinositol 3-kinase binding |
| response to platelet-derived growth factor |
| tau-protein kinase activity |
| negative regulation of synapse organization |
| negative regulation of reactive oxygen species biosynthetic process |
| ephrin receptor binding |
| detection of mechanical stimulus involved in sensory perception |
| regulation of defense response to virus by virus |
| positive regulation of protein targeting to membrane |
| dendritic spine organization |
| peptidyl-tyrosine autophosphorylation |
| disordered domain specific binding |
| negative regulation of signal transduction in absence of ligand |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of cofactor metabolic process |
| regulation of protein targeting to membrane |
| T cell proliferation |
| regulation of calcium ion import |
| cellular response to amyloid-beta |
| alpha-tubulin binding |
| neuron projection organization |
| detection of mechanical stimulus |
| negative regulation of cellular response to oxidative stress |
| negative regulation of oxidative stress-induced cell death |
| tau protein binding |
| cellular component maintenance |
| non-membrane spanning protein tyrosine kinase activity |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| negative regulation of response to oxidative stress |
| response to amyloid-beta |
| T cell costimulation |
| negative regulation of reactive oxygen species metabolic process |
| positive regulation of protein tyrosine kinase activity |
| lymphocyte costimulation |
| dendrite morphogenesis |
| extrinsic component of cytoplasmic side of plasma membrane |
| regulation of oxidative stress-induced cell death |
| regulation of glutamate receptor signaling pathway |
| cellular response to nutrient |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of tyrosine phosphorylation of STAT protein |
| cellular response to amino acid stimulus |
| cell body |
| negative regulation of protein ubiquitination |
| regulation of cellular response to oxidative stress |
| positive regulation of protein localization to nucleus |
| sensory perception of pain |
| regulation of tyrosine phosphorylation of STAT protein |
| actin filament |
| Schaffer collateral - CA1 synapse |
| regulation of protein targeting |
| lymphocyte proliferation |
| negative regulation of protein modification by small protein conjugation or removal |
| regulation of response to oxidative stress |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| mononuclear cell proliferation |
| regulation of reactive oxygen species biosynthetic process |
| feeding behavior |
| ephrin receptor signaling pathway |
| postsynapse organization |
| positive regulation of receptor signaling pathway via STAT |
| protein tyrosine kinase activity |
| regulation of protein tyrosine kinase activity |
| positive regulation of neuron death |
| regulation of postsynapse organization |
| leukocyte proliferation |
| regulation of calcium ion transport into cytosol |
| heart process |
| negative regulation of extrinsic apoptotic signaling pathway |
| dendrite development |
| stimulatory C-type lectin receptor signaling pathway |
| response to amino acid |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of protein localization to nucleus |
| response to hydrogen peroxide |
| neuron migration |
| regulation of phosphatidylinositol 3-kinase signaling |
| detection of external stimulus |
| detection of abiotic stimulus |
| positive regulation of protein localization to membrane |
| ion channel binding |
| response to ethanol |
| regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of protein catabolic process |
| regulation of receptor signaling pathway via STAT |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| platelet activation |
| Fc-gamma receptor signaling pathway |
| peptidyl-tyrosine phosphorylation |
| negative regulation of neuron apoptotic process |
| learning |
| peptidyl-tyrosine modification |
| regulation of calcium ion transmembrane transport |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of cell shape |
| positive regulation of intracellular protein transport |
| regulation of extrinsic apoptotic signaling pathway |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| positive regulation of protein kinase B signaling |
| sensory perception of mechanical stimulus |
| positive regulation of endopeptidase activity |
| T cell receptor signaling pathway |
| regulation of reactive oxygen species metabolic process |
| negative regulation of cell projection organization |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of protein localization to membrane |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of peptidase activity |
| protein autophosphorylation |
| response to reactive oxygen species |
| regulation of protein ubiquitination |
| positive regulation of T cell activation |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| positive regulation of intracellular transport |
| cellular response to acid chemical |
| response to mechanical stimulus |
| response to nutrient |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of synapse organization |
| regulation of protein kinase B signaling |
| negative regulation of apoptotic signaling pathway |
| membrane raft |
| regulation of synapse structure or activity |
| regulation of protein modification by small protein conjugation or removal |
| regulation of intracellular protein transport |
| response to alcohol |
| innate immune response-activating signal transduction |
| cellular response to nutrient levels |
| T cell activation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of cysteine-type endopeptidase activity |
| Fc receptor signaling pathway |
| regulation of calcium ion transport |
| calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| postsynaptic density |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| learning or memory |
| axon guidance |
| neuron projection guidance |
| cellular response to extracellular stimulus |
| cellular response to peptide hormone stimulus |
| endosome |
| synapse organization |
| positive regulation of neuron projection development |
| blood coagulation |
| antigen receptor-mediated signaling pathway |
| coagulation |
| divalent metal ion transport |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| cognition |
| divalent inorganic cation transport |
| response to antibiotic |
| negative regulation of catabolic process |
| regulation of neuron death |
| regulation of T cell activation |
| positive regulation of cellular protein localization |
| cellular response to peptide |
| phagocytosis |
| regulation of cation transmembrane transport |
| cellular response to external stimulus |
| signaling receptor binding |
| positive regulation of innate immune response |
| response to acid chemical |
| enzyme binding |
| glutamatergic synapse |
| regulation of intracellular transport |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| positive regulation of neuron differentiation |
| MAPK cascade |
| axonogenesis |
| leukocyte migration |
| positive regulation of cell projection organization |
| lymphocyte activation |
| regulation of protein catabolic process |
| response to oxidative stress |
| forebrain development |
| regulation of metal ion transport |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| cellular response to drug |
| axon development |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| dendrite |
| positive regulation of protein transport |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| positive regulation of neurogenesis |
| response to peptide |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| wound healing |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of body fluid levels |
| regulation of neuron projection development |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| response to toxic substance |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| response to extracellular stimulus |
| response to growth factor |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| positive regulation of nervous system development |
| regulation of cellular protein localization |
| positive regulation of cell development |
| detection of stimulus involved in sensory perception |
| chemotaxis |
| taxis |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| behavior |
| response to wounding |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| adaptive immune response |
| activation of immune response |
| metal ion transport |
| regulation of cell activation |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| neuron projection development |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| detection of stimulus |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of ion transport |
| viral process |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| head development |
| symbiotic process |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| cation transport |
| positive regulation of immune response |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cellular localization |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| cell migration |
| positive regulation of cell differentiation |
| sensory perception |
| protein phosphorylation |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| regulation of catabolic process |
| negative regulation of cell death |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| YM155 0.001μM R08 exp432 | 1.79 |
| Centrinone 0.5μM R07 exp343 | 2.15 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7875
- Expression level (log2 read counts): 4.09
Expression Distribution
FYN Expression in NALM6 Cells: 4.09
