G3BP2
Gene Information
- Official Symbol: G3BP2
- Official Name: G3BP stress granule assembly factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9908
- UniProt: Q9UN86
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Probable scaffold protein that may be involved in mRNA transport. {ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| NTF2 |
| RRM 1 |
GO Terms
| positive regulation of stress granule assembly |
| regulation of stress granule assembly |
| cytoplasmic sequestering of NF-kappaB |
| stress granule assembly |
| cytoplasmic sequestering of transcription factor |
| receptor signaling complex adaptor activity |
| cytoplasmic sequestering of protein |
| cytoplasmic stress granule |
| positive regulation of organelle assembly |
| negative regulation of NF-kappaB transcription factor activity |
| maintenance of protein location |
| mRNA transport |
| ribonucleoprotein complex |
| negative regulation of DNA-binding transcription factor activity |
| mRNA binding |
| maintenance of location |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| RNA localization |
| regulation of organelle assembly |
| ribonucleoprotein complex assembly |
| nucleobase-containing compound transport |
| ribonucleoprotein complex subunit organization |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| small GTPase mediated signal transduction |
| protein homooligomerization |
| regulation of DNA-binding transcription factor activity |
| regulation of protein complex assembly |
| ribonucleoprotein complex biogenesis |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| positive regulation of organelle organization |
| viral process |
| organelle assembly |
| innate immune response |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| defense response to other organism |
| regulation of cellular component biogenesis |
| negative regulation of molecular function |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| RNA binding |
| protein-containing complex assembly |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TRAIL 50ng/ml R00 exp36 | -2.07 |
| Cannabidiol 20μM R08 exp466 | -1.89 |
| Vinblastine 0.015μM R05 exp208 | -1.87 |
| Dinaciclib 0.007μM R07 exp355 | -1.77 |
| BVD-523 15μM R02 exp67 | -1.71 |
| Resveratrol 16μM R03 exp147 | 2.07 |
| QNZ 0.01μM R05 exp241 | 2.29 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5056
- Expression level (log2 read counts): 7.67
Expression Distribution
G3BP2 Expression in NALM6 Cells: 7.67
