GINS3

Entrez Summary: N/A
UniProt Summary: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. {ECO:0000269|PubMed:17417653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.14
Etoposide 0.1μM R05 exp198	-1.86

Global Fraction of Cell Lines Where Essential: 611/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	21/28
blood	25/28
bone	24/26
breast	25/33
central nervous system	45/56
cervix	4/4
colorectal	13/17
esophagus	9/13
fibroblast	1/1
gastric	15/16
kidney	15/21
liver	18/20
lung	62/75
lymphocyte	13/16
ovary	21/26
pancreas	17/24
peripheral nervous system	15/16
plasma cell	11/15
prostate	1/1
skin	24/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	19/22
urinary tract	22/29
uterus	4/5

Expression Distribution