Entrez Summary: The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010].
UniProt Summary: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Pfam DomainsGO Terms
Pfam Domains
Connexin
Connexin CCC
GO Terms
gap junction-mediated intercellular transport
gap junction hemi-channel activity
intercellular transport
connexin complex
visual perception
sensory perception of light stimulus
sensory perception
transmembrane transport
nervous system process
integral component of plasma membrane
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)