GNA12
Gene Information
- Official Symbol: GNA12
- Official Name: G protein subunit alpha 12
- Aliases and Previous Symbols: N/A
- Entrez ID: 2768
- UniProt: Q03113
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Arf |
| G-alpha |
GO Terms
| D5 dopamine receptor binding |
| G-protein beta/gamma-subunit complex binding |
| regulation of fibroblast migration |
| heterotrimeric G-protein complex |
| brush border membrane |
| lateral plasma membrane |
| embryonic digit morphogenesis |
| G protein-coupled receptor binding |
| Rho protein signal transduction |
| regulation of TOR signaling |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| platelet activation |
| limb morphogenesis |
| appendage morphogenesis |
| regulation of cell shape |
| regulation of ubiquitin-dependent protein catabolic process |
| limb development |
| appendage development |
| regulation of proteasomal protein catabolic process |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of proteolysis involved in cellular protein catabolic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| Ras protein signal transduction |
| regulation of cellular protein catabolic process |
| blood coagulation |
| coagulation |
| hemostasis |
| small GTPase mediated signal transduction |
| GTPase activity |
| in utero embryonic development |
| regulation of protein catabolic process |
| GTP binding |
| focal adhesion |
| wound healing |
| regulation of cell morphogenesis |
| regulation of body fluid levels |
| embryonic morphogenesis |
| response to wounding |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of proteolysis |
| regulation of cellular catabolic process |
| regulation of cell migration |
| regulation of cell motility |
| embryo development |
| regulation of locomotion |
| regulation of catabolic process |
| regulation of cellular component movement |
| response to drug |
| regulation of anatomical structure morphogenesis |
| cell activation |
| G protein-coupled receptor signaling pathway |
| intracellular signal transduction |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rotenone 2μM R00 exp33 | 1.74 |
| Nocodazole 0.2μM R02 exp64 | 1.87 |
| Nocodazole 0.1μM R03 exp94 | 2.38 |
| R-DABN 8μM R03 exp111 | 3.19 |
| SB743921 0.001μM R05 exp244 | 3.32 |
| Vinblastine 0.015μM R05 exp208 | 3.54 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6247
- Expression level (log2 read counts): 5.2
Expression Distribution
GNA12 Expression in NALM6 Cells: 5.2
