GPRASP1
Gene Information
- Official Symbol: GPRASP1
- Official Name: G protein-coupled receptor associated sorting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9737
- UniProt: Q5JY77
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010].
- UniProt Summary: Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. {ECO:0000269|PubMed:12142540, ECO:0000269|PubMed:15452121, ECO:0000269|PubMed:23954414}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14923
- Expression level (log2 read counts): 1.89
GPRASP1 Expression in NALM6 Cells: 1.89
