GUCY1B3
Gene Information
- Official Symbol: GUCY1B1
- Official Name: guanylate cyclase 1 soluble subunit beta 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2983
- UniProt: Q02153
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. {ECO:0000250|UniProtKB:P16068, ECO:0000269|PubMed:1352257}.
Pfam Domains GO Terms
Pfam Domains
| HNOBA |
| HNOB |
| Guanylate cyc |
GO Terms
| trans-synaptic signaling by nitric oxide, modulating synaptic transmission |
| nitric oxide-cGMP-mediated signaling pathway |
| trans-synaptic signaling by soluble gas, modulating synaptic transmission |
| guanylate cyclase complex, soluble |
| trans-synaptic signaling by soluble gas |
| synaptic signaling by nitric oxide |
| trans-synaptic signaling by nitric oxide |
| guanylate cyclase activity |
| trans-synaptic signaling, modulating synaptic transmission |
| cGMP biosynthetic process |
| cellular response to nitric oxide |
| cGMP metabolic process |
| response to nitric oxide |
| cellular response to reactive nitrogen species |
| nitric oxide mediated signal transduction |
| cyclic purine nucleotide metabolic process |
| cyclic nucleotide biosynthetic process |
| cGMP-mediated signaling |
| presynaptic active zone |
| cyclic nucleotide metabolic process |
| response to bronchodilator |
| cellular response to reactive oxygen species |
| heme binding |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| cyclic-nucleotide-mediated signaling |
| response to reactive oxygen species |
| signaling receptor activity |
| cellular response to inorganic substance |
| cellular response to oxidative stress |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| purine-containing compound metabolic process |
| response to oxidative stress |
| GTP binding |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| synaptic signaling |
| response to inorganic substance |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| carbohydrate derivative biosynthetic process |
| cellular response to nitrogen compound |
| organophosphate metabolic process |
| response to drug |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| cell-cell signaling |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| intracellular signal transduction |
| cellular response to stress |
| small molecule metabolic process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.11 to 0.175μM on day4 R07 exp413 | 1.7 |
| Ribavirin 10μM R01 exp52 | 2.28 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18452
- Expression level (log2 read counts): -2.69
Expression Distribution
GUCY1B3 Expression in NALM6 Cells: -2.69
