GUF1
Gene Information
- Official Symbol: GUF1
- Official Name: GUF1 homolog, GTPase
- Aliases and Previous Symbols: N/A
- Entrez ID: 60558
- UniProt: Q8N442
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
- UniProt Summary: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255|HAMAP-Rule:MF_03137}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9762
- Expression level (log2 read counts): 6.51
GUF1 Expression in NALM6 Cells: 6.51
