HEATR2
Gene Information
- Official Symbol: DNAAF5
- Official Name: dynein axonemal assembly factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 54919
- UniProt: Q86Y56
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013].
- UniProt Summary: Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. {ECO:0000269|PubMed:23040496, ECO:0000269|PubMed:25232951}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 980
- Expression level (log2 read counts): 5.61
HEATR2 Expression in NALM6 Cells: 5.61
