HNRNPL
Gene Information
- Official Symbol: HNRNPL
- Official Name: heterogeneous nuclear ribonucleoprotein L
- Aliases and Previous Symbols: N/A
- Entrez ID: 3191
- UniProt: P14866
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1123
- Expression level (log2 read counts): 9.14
HNRNPL Expression in NALM6 Cells: 9.14
