IL13RA1
Gene Information
- Official Symbol: IL13RA1
- Official Name: interleukin 13 receptor subunit alpha 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3597
- UniProt: P78552
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008].
- UniProt Summary: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18315
- Expression level (log2 read counts): 1.34
IL13RA1 Expression in NALM6 Cells: 1.34
