IL18R1
Gene Information
- Official Symbol: IL18R1
- Official Name: interleukin 18 receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8809
- UniProt: Q13478
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:8626725, ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| TIR |
GO Terms
| interleukin-18 binding |
| interleukin-18 receptor activity |
| interleukin-18 receptor complex |
| positive regulation of T-helper 1 cell cytokine production |
| regulation of T-helper 1 cell cytokine production |
| cellular response to interleukin-18 |
| interleukin-18-mediated signaling pathway |
| interleukin-1 receptor activity |
| T-helper 1 cell differentiation |
| response to interleukin-18 |
| T-helper 1 type immune response |
| positive regulation of T cell cytokine production |
| positive regulation of T-helper 1 type immune response |
| CD4-positive, alpha-beta T cell differentiation involved in immune response |
| T-helper cell differentiation |
| regulation of T-helper 1 type immune response |
| alpha-beta T cell activation involved in immune response |
| alpha-beta T cell differentiation involved in immune response |
| regulation of T cell cytokine production |
| T cell differentiation involved in immune response |
| CD4-positive, alpha-beta T cell differentiation |
| CD4-positive, alpha-beta T cell activation |
| negative regulation of cold-induced thermogenesis |
| positive regulation of T cell mediated immunity |
| alpha-beta T cell differentiation |
| positive regulation of cytokine production involved in immune response |
| natural killer cell activation |
| alpha-beta T cell activation |
| T cell activation involved in immune response |
| positive regulation of interferon-gamma production |
| regulation of T cell mediated immunity |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of cytokine production involved in immune response |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| regulation of NIK/NF-kappaB signaling |
| lymphocyte activation involved in immune response |
| positive regulation of leukocyte mediated immunity |
| T cell differentiation |
| regulation of production of molecular mediator of immune response |
| regulation of cold-induced thermogenesis |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of adaptive immune response |
| signaling receptor activity |
| regulation of leukocyte mediated immunity |
| positive regulation of immune effector process |
| T cell activation |
| lymphocyte differentiation |
| positive regulation of DNA-binding transcription factor activity |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| leukocyte differentiation |
| lymphocyte activation |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| regulation of immune effector process |
| inflammatory response |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| immune system development |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| positive regulation of immune response |
| leukocyte activation |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| cell activation |
| immune effector process |
| response to cytokine |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| defense response |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| B02 10μM R08 exp453 | -1.8 |
| Brefeldin A 0.02μM R00 exp8 | 1.82 |
| BI-6727 0.0125μM R03 exp97 | 1.86 |
| Nutlin-3A 1.6μM R06 exp294 | 2.05 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12847
- Expression level (log2 read counts): -1.82
Expression Distribution
IL18R1 Expression in NALM6 Cells: -1.82
