INHA
Gene Information
- Official Symbol: INHA
- Official Name: inhibin subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 3623
- UniProt: P05111
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
GO Terms
| inhibin B complex |
| inhibin A complex |
| inhibin-betaglycan-ActRII complex |
| negative regulation of follicle-stimulating hormone secretion |
| negative regulation of interferon-gamma biosynthetic process |
| negative regulation of B cell differentiation |
| hemoglobin biosynthetic process |
| inhibin binding |
| regulation of follicle-stimulating hormone secretion |
| positive regulation of follicle-stimulating hormone secretion |
| negative regulation of gonadotropin secretion |
| negative regulation of macrophage differentiation |
| positive regulation of gonadotropin secretion |
| hemoglobin metabolic process |
| regulation of gonadotropin secretion |
| regulation of interferon-gamma biosynthetic process |
| regulation of macrophage differentiation |
| regulation of B cell differentiation |
| negative regulation of B cell activation |
| negative regulation of cytokine biosynthetic process |
| negative regulation of interferon-gamma production |
| transforming growth factor beta receptor binding |
| regulation of endocrine process |
| negative regulation of myeloid leukocyte differentiation |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| photoreceptor inner segment |
| ovarian follicle development |
| negative regulation of lymphocyte differentiation |
| SMAD protein signal transduction |
| photoreceptor outer segment |
| regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of hormone secretion |
| negative regulation of myeloid cell differentiation |
| erythrocyte differentiation |
| female gonad development |
| erythrocyte homeostasis |
| development of primary female sexual characteristics |
| hormone activity |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cytokine biosynthetic process |
| female sex differentiation |
| myeloid cell homeostasis |
| regulation of myeloid leukocyte differentiation |
| positive regulation of hormone secretion |
| male gonad development |
| development of primary male sexual characteristics |
| negative regulation of hemopoiesis |
| negative regulation of lymphocyte activation |
| cell cycle arrest |
| male sex differentiation |
| growth factor activity |
| regulation of lymphocyte differentiation |
| cytokine activity |
| negative regulation of leukocyte activation |
| negative regulation of cell activation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| homeostasis of number of cells |
| negative regulation of secretion by cell |
| regulation of B cell activation |
| gonad development |
| development of primary sexual characteristics |
| myeloid cell differentiation |
| regulation of myeloid cell differentiation |
| negative regulation of secretion |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| sex differentiation |
| regulation of hormone secretion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| signaling receptor binding |
| neuronal cell body |
| positive regulation of secretion by cell |
| reproductive structure development |
| reproductive system development |
| positive regulation of secretion |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| negative regulation of transport |
| protein heterodimerization activity |
| skeletal system development |
| regulation of lymphocyte activation |
| regulation of hormone levels |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| regulation of system process |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| developmental process involved in reproduction |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of secretion |
| negative regulation of developmental process |
| positive regulation of transport |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dinaciclib 0.007μM R07 exp355 | 1.74 |
| THZ531 0.11μM R07 exp409 | 1.83 |
| Trichostatin-A 0.06μM R07 exp415 | 1.96 |
| Docetaxel 0.002μM R01 exp45 | 1.99 |
| Nifuroxazide 1μM R01 exp51 | 2.38 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4648
- Expression level (log2 read counts): -7.68
Expression Distribution
INHA Expression in NALM6 Cells: -7.68
