ITM2C
Gene Information
- Official Symbol: ITM2C
- Official Name: integral membrane protein 2C
- Aliases and Previous Symbols: N/A
- Entrez ID: 81618
- UniProt: Q9NQX7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| BRICHOS |
GO Terms
| negative regulation of amyloid precursor protein biosynthetic process |
| regulation of amyloid precursor protein biosynthetic process |
| negative regulation of glycoprotein biosynthetic process |
| negative regulation of glycoprotein metabolic process |
| regulation of glycoprotein biosynthetic process |
| regulation of glycoprotein metabolic process |
| positive regulation of extrinsic apoptotic signaling pathway |
| amyloid-beta binding |
| negative regulation of neuron projection development |
| regulation of extrinsic apoptotic signaling pathway |
| positive regulation of apoptotic signaling pathway |
| negative regulation of cell projection organization |
| negative regulation of neuron differentiation |
| lysosome |
| negative regulation of neurogenesis |
| lysosomal membrane |
| negative regulation of nervous system development |
| negative regulation of cell development |
| regulation of apoptotic signaling pathway |
| regulation of neuron projection development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| Golgi apparatus |
| neuron differentiation |
| negative regulation of protein metabolic process |
| negative regulation of multicellular organismal process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of cell death |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| S-trityl-L-cysteine 0.5μM R05 exp243 | 1.74 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16758
- Expression level (log2 read counts): 5.71
Expression Distribution
ITM2C Expression in NALM6 Cells: 5.71
