JUND
Gene Information
- Official Symbol: JUND
- Official Name: JunD proto-oncogene, AP-1 transcription factor subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 3727
- UniProt: P17535
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor binding AP-1 sites. {ECO:0000269|PubMed:9989505}.
Pfam Domains GO Terms
Pfam Domains
| bZIP 1 |
| Jun |
| bZIP 2 |
GO Terms
| transcription factor AP-1 complex |
| osteoblast development |
| nuclear receptor binding |
| protein-DNA complex |
| positive regulation of osteoblast differentiation |
| cellular response to calcium ion |
| positive regulation of ossification |
| response to cAMP |
| regulation of osteoblast differentiation |
| chromatin |
| osteoblast differentiation |
| response to organophosphorus |
| circadian rhythm |
| response to calcium ion |
| response to purine-containing compound |
| regulation of ossification |
| cellular response to metal ion |
| transcription factor complex |
| response to mechanical stimulus |
| transcription regulatory region DNA binding |
| cellular response to inorganic substance |
| nuclear chromatin |
| ossification |
| rhythmic process |
| aging |
| transcription coactivator activity |
| response to light stimulus |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| transcription factor binding |
| enzyme binding |
| response to metal ion |
| response to peptide hormone |
| response to radiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| response to peptide |
| transcription by RNA polymerase II |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| response to inorganic substance |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| response to bacterium |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| response to hormone |
| response to organic cyclic compound |
| positive regulation of cell differentiation |
| response to organonitrogen compound |
| response to drug |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| EPZ-5676 30μM R05 exp233 | 1.9 |
| Betulinic acid 10 to 15μM on day4 R05 exp222 | 2.23 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NUP160 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18131
- Expression level (log2 read counts): 5.11
Expression Distribution
JUND Expression in NALM6 Cells: 5.11
