Entrez Summary: This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Kinesin
GO Terms
male germ cell nucleus
kinesin complex
microtubule motor activity
ATPase activity
microtubule binding
microtubule-based movement
microtubule
microtubule-based process
ATP binding
movement of cell or subcellular component
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)