KLK2
Gene Information
- Official Symbol: KLK2
- Official Name: kallikrein related peptidase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3817
- UniProt: P20151
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012].
- UniProt Summary: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14374
- Expression level (log2 read counts): 1.12
KLK2 Expression in NALM6 Cells: 1.12
