LACC1
Gene Information
- Official Symbol: LACC1
- Official Name: laccase domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 144811
- UniProt: Q8IV20
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017].
- UniProt Summary: Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis. {ECO:0000250|UniProtKB:Q8BZT9}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17379
- Expression level (log2 read counts): 1.72
LACC1 Expression in NALM6 Cells: 1.72
