LEPREL4

• Official Symbol: P3H4
• Official Name: prolyl 3-hydroxylase family member 4 (inactive)
• Aliases and Previous Symbols: N/A
• Entrez ID: 10609
• UniProt: Q92791
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. {ECO:0000250|UniProtKB:Q8K2B0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 5102
• Expression level (log2 read counts): 3.7

Expression Distribution

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LEPREL4 Expression in NALM6 Cells: 3.7