MAP1A

Gene Information

Official Symbol: MAP1A
Official Name: microtubule associated protein 1A
Aliases and Previous Symbols: N/A
Entrez ID: 4130
UniProt: P78559
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements.

Pfam Domains GO Terms

Pfam Domains

No Pfam Domain information is available for this gene.

GO Terms

primary dendrite

retrograde axonal protein transport

dendritic branch

dendritic microtubule

regulation of protein localization to microtubule

negative regulation of protein localization to microtubule

voluntary musculoskeletal movement

anterograde axonal protein transport

protein localization to presynapse

neuron projection maintenance

axo-dendritic protein transport

cytoskeletal adaptor activity

positive regulation of protein localization to cell surface

retrograde axonal transport

axon initial segment

regulation of microtubule depolymerization

microtubule associated complex

neuron cellular homeostasis

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

dendritic shaft

regulation of protein localization to cell surface

neuron projection organization

musculoskeletal movement

multicellular organismal movement

anterograde axonal transport

tau protein binding

negative regulation of ubiquitin-dependent protein catabolic process

tubulin binding

axonal transport

negative regulation of proteasomal protein catabolic process

axon cytoplasm

protein localization to synapse

axo-dendritic transport

protein transport along microtubule

microtubule-based protein transport

negative regulation of proteolysis involved in cellular protein catabolic process

associative learning

regulation of microtubule polymerization or depolymerization

regulation of protein depolymerization

negative regulation of cellular protein catabolic process

cell projection

dendrite development

negative regulation of cellular protein localization

regulation of protein complex disassembly

memory

regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein catabolic process

learning

regulation of ubiquitin-dependent protein catabolic process

transport along microtubule

cytoskeleton-dependent intracellular transport

microtubule-based transport

regulation of proteasomal protein catabolic process

regulation of microtubule cytoskeleton organization

regulation of synaptic plasticity

structural molecule activity

regulation of proteolysis involved in cellular protein catabolic process

regulation of microtubule-based process

microtubule binding

regulation of cellular protein catabolic process

negative regulation of cellular catabolic process

learning or memory

actin binding

synapse

microtubule-based movement

axon

cognition

negative regulation of catabolic process

microtubule

neuron projection

positive regulation of cellular protein localization

anatomical structure homeostasis

regulation of supramolecular fiber organization

negative regulation of proteolysis

neuronal cell body

axonogenesis

regulation of protein catabolic process

axon development

dendrite

cell morphogenesis involved in neuron differentiation

modulation of chemical synaptic transmission

regulation of trans-synaptic signaling

microtubule cytoskeleton organization

neuron projection morphogenesis

plasma membrane bounded cell projection morphogenesis

cell projection morphogenesis

cell part morphogenesis

regulation of cellular protein localization

regulation of cytoskeleton organization

cell morphogenesis involved in differentiation

behavior

neuron projection development

microtubule-based process

cell morphogenesis

regulation of proteolysis

neuron development

cellular component morphogenesis

regulation of cellular catabolic process

cellular homeostasis

regulation of cellular localization

intracellular protein transport

regulation of catabolic process

neuron differentiation

regulation of protein localization

negative regulation of cellular protein metabolic process

negative regulation of protein metabolic process

cytoskeleton organization

plasma membrane bounded cell projection organization

cell projection organization

regulation of organelle organization

nervous system process

protein transport

intracellular transport

generation of neurons

peptide transport

movement of cell or subcellular component

amide transport

cellular protein localization

cellular macromolecule localization

establishment of protein localization

neurogenesis

homeostatic process

cell development

establishment of localization in cell

nitrogen compound transport

system process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Mdivi-1 15μM R05 exp217	-2.22
WNT3A 44ng/ml R08 exp537	-1.92
Etoposide 0.3μM R05 exp199	-1.77
UMK57 0.6μM R03 exp107	-1.74

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4207
Expression level (log2 read counts): 5.71

Expression Distribution