MED28
Gene Information
- Official Symbol: MED28
- Official Name: mediator complex subunit 28
- Aliases and Previous Symbols: N/A
- Entrez ID: 80306
- UniProt: Q9H204
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2024
- Expression level (log2 read counts): 7.05
MED28 Expression in NALM6 Cells: 7.05
