MED8
Gene Information
- Official Symbol: MED8
- Official Name: mediator complex subunit 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 112950
- UniProt: Q96G25
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2033
- Expression level (log2 read counts): 4.52
MED8 Expression in NALM6 Cells: 4.52
