MGST2
Gene Information
- Official Symbol: MGST2
- Official Name: microsomal glutathione S-transferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4258
- UniProt: Q99735
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
Pfam Domains GO Terms
Pfam Domains
| MAPEG |
GO Terms
| leukotriene-C4 synthase activity |
| glutathione biosynthetic process |
| nonribosomal peptide biosynthetic process |
| leukotriene biosynthetic process |
| glutathione peroxidase activity |
| glutathione derivative biosynthetic process |
| glutathione derivative metabolic process |
| glutathione transferase activity |
| leukotriene metabolic process |
| membrane lipid catabolic process |
| cellular modified amino acid biosynthetic process |
| enzyme activator activity |
| icosanoid biosynthetic process |
| glutathione metabolic process |
| cellular oxidant detoxification |
| fatty acid derivative biosynthetic process |
| cellular detoxification |
| icosanoid metabolic process |
| detoxification |
| xenobiotic metabolic process |
| positive regulation of inflammatory response |
| fatty acid derivative metabolic process |
| nuclear envelope |
| sulfur compound biosynthetic process |
| cellular response to xenobiotic stimulus |
| cellular lipid catabolic process |
| cellular modified amino acid metabolic process |
| membrane lipid metabolic process |
| cofactor biosynthetic process |
| cellular response to toxic substance |
| lipid catabolic process |
| response to xenobiotic stimulus |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| regulation of inflammatory response |
| sulfur compound metabolic process |
| peptide biosynthetic process |
| cofactor metabolic process |
| positive regulation of defense response |
| response to toxic substance |
| amide biosynthetic process |
| peptide metabolic process |
| small molecule biosynthetic process |
| positive regulation of response to external stimulus |
| intracellular membrane-bounded organelle |
| response to bacterium |
| regulation of defense response |
| cellular amide metabolic process |
| response to lipid |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| endoplasmic reticulum |
| organic acid metabolic process |
| response to nitrogen compound |
| regulation of response to external stimulus |
| lipid metabolic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of response to stress |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pimelic-diphenylamide-106 0.5μM R00 exp27 | 1.71 |
| Rifampicin 1μM R00 exp31 | 1.72 |
| Alpha-Amanitin 0.5μM R00 exp5 | 2.24 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12922
- Expression level (log2 read counts): 2.42
Expression Distribution
MGST2 Expression in NALM6 Cells: 2.42
