MLC1
Gene Information
- Official Symbol: MLC1
- Official Name: modulator of VRAC current 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23209
- UniProt: Q15049
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
- UniProt Summary: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. {ECO:0000269|PubMed:22328087}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7126
- Expression level (log2 read counts): -2.47
MLC1 Expression in NALM6 Cells: -2.47
