MMP16
Gene Information
- Official Symbol: MMP16
- Official Name: matrix metallopeptidase 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 4325
- UniProt: P51512
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13327
- Expression level (log2 read counts): -2.51
MMP16 Expression in NALM6 Cells: -2.51
