Entrez Summary: This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009].
UniProt Summary: Enhances the phosphorylation and activation of AKT1 and AKT2. {ECO:0000269|PubMed:10983986}.
Pfam DomainsGO Terms
Pfam Domains
TCL1 MTCP1
GO Terms
protein serine/threonine kinase activator activity
positive regulation of peptidyl-serine phosphorylation
regulation of peptidyl-serine phosphorylation
positive regulation of protein serine/threonine kinase activity
protein kinase binding
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
protein-containing complex
positive regulation of transferase activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)