MTNR1B
Gene Information
- Official Symbol: MTNR1B
- Official Name: melatonin receptor 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 4544
- UniProt: P49286
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008].
- UniProt Summary: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srx |
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| melatonin receptor activity |
| positive regulation of circadian sleep/wake cycle, non-REM sleep |
| regulation of neuronal action potential |
| negative regulation of transmission of nerve impulse |
| positive regulation of circadian sleep/wake cycle, sleep |
| negative regulation of cGMP-mediated signaling |
| positive regulation of transmission of nerve impulse |
| regulation of circadian sleep/wake cycle, non-REM sleep |
| negative regulation of delayed rectifier potassium channel activity |
| negative regulation of cytosolic calcium ion concentration |
| negative regulation of voltage-gated potassium channel activity |
| regulation of cGMP-mediated signaling |
| positive regulation of circadian rhythm |
| regulation of circadian sleep/wake cycle, sleep |
| regulation of transmission of nerve impulse |
| regulation of delayed rectifier potassium channel activity |
| negative regulation of potassium ion transmembrane transporter activity |
| regulation of circadian sleep/wake cycle |
| negative regulation of potassium ion transmembrane transport |
| negative regulation of nervous system process |
| positive regulation of behavior |
| negative regulation of potassium ion transport |
| negative regulation of insulin secretion |
| negative regulation of cation channel activity |
| negative regulation of peptide hormone secretion |
| regulation of action potential |
| regulation of potassium ion transmembrane transporter activity |
| positive regulation of blood vessel diameter |
| negative regulation of hormone secretion |
| positive regulation of nervous system process |
| negative regulation of ion transmembrane transporter activity |
| regulation of behavior |
| negative regulation of transporter activity |
| regulation of potassium ion transmembrane transport |
| negative regulation of cation transmembrane transport |
| negative regulation of ion transmembrane transport |
| regulation of potassium ion transport |
| regulation of circadian rhythm |
| negative regulation of transmembrane transport |
| negative regulation of protein secretion |
| regulation of nervous system process |
| negative regulation of peptide secretion |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| negative regulation of neuron apoptotic process |
| negative regulation of ion transport |
| vascular process in circulatory system |
| regulation of cation channel activity |
| regulation of insulin secretion |
| negative regulation of protein transport |
| glucose homeostasis |
| negative regulation of establishment of protein localization |
| carbohydrate homeostasis |
| negative regulation of secretion by cell |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| regulation of peptide hormone secretion |
| negative regulation of secretion |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| regulation of transporter activity |
| regulation of neuron death |
| camera-type eye development |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| eye development |
| visual system development |
| sensory system development |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| regulation of hormone levels |
| sensory organ development |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| regulation of protein localization |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.412 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6531
- Expression level (log2 read counts): -5.6
Expression Distribution
MTNR1B Expression in NALM6 Cells: -5.6
