NAA40
Gene Information
- Official Symbol: N/AA40
- Official Name: N-alpha-acetyltransferase 40, NatD catalytic subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 79829
- UniProt: Q86UY6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha- acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg- Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8VE10, ECO:0000269|PubMed:21935442, ECO:0000269|PubMed:25619998, ECO:0000269|PubMed:26666750}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4869
- Expression level (log2 read counts): 6.04
NAA40 Expression in NALM6 Cells: 6.04
