NELFCD
Gene Information
- Official Symbol: NELFCD
- Official Name: negative elongation factor complex member C/D
- Aliases and Previous Symbols: N/A
- Entrez ID: 51497
- UniProt: Q8IXH7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| TH1 |
GO Terms
| NELF complex |
| negative regulation of transcription elongation from RNA polymerase II promoter |
| negative regulation of DNA-templated transcription, elongation |
| regulation of transcription elongation from RNA polymerase II promoter |
| positive regulation of viral transcription |
| regulation of DNA-templated transcription, elongation |
| regulation of viral transcription |
| transcription elongation from RNA polymerase II promoter |
| DNA-templated transcription, elongation |
| positive regulation of viral process |
| regulation of viral process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| transcription by RNA polymerase II |
| positive regulation of multi-organism process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of multi-organism process |
| negative regulation of transcription by RNA polymerase II |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 1μM R00 exp19 | -2.1 |
| Pimelic-diphenylamide-106 5μM R00 exp28 | -1.93 |
| 5-Fluorouracil 20μM R00 exp2 | -1.92 |
| MLN-4924 2μM R00 exp22 | -1.9 |
| CI-1040 9.5μM R08 exp472 | -1.89 |
| SNS-032 15μM R08 exp443 | -1.8 |
| Tozasertib 0.1μM R07 exp414 | -1.75 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 15/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 2/25 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1096
- Expression level (log2 read counts): 7.01
Expression Distribution
NELFCD Expression in NALM6 Cells: 7.01
