NHS
Gene Information
- Official Symbol: NHS
- Official Name: NHS actin remodeling regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 4810
- UniProt: Q6T4R5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein containing four conserved nuclear localization signals. The encoded protein functions in eye, tooth, craniofacial and brain development, and it can regulate actin remodeling and cell morphology. Mutations in this gene have been shown to cause Nance-Horan syndrome, and also X-linked cataract-40. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2014].
- UniProt Summary: May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7323
- Expression level (log2 read counts): -2.11
NHS Expression in NALM6 Cells: -2.11
