NMI
Gene Information
- Official Symbol: NMI
- Official Name: N-myc and STAT interactor
- Aliases and Previous Symbols: N/A
- Entrez ID: 9111
- UniProt: Q13287
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
Pfam Domains GO Terms
Pfam Domains
| IFP 35 N |
| NID |
GO Terms
| negative regulation of interferon-beta biosynthetic process |
| negative regulation of interferon-alpha biosynthetic process |
| positive regulation of protein K48-linked ubiquitination |
| regulation of protein K48-linked ubiquitination |
| negative regulation of interferon-alpha production |
| regulation of interferon-alpha biosynthetic process |
| regulation of interferon-beta biosynthetic process |
| positive regulation of protein polyubiquitination |
| negative regulation of interferon-beta production |
| regulation of protein polyubiquitination |
| regulation of interferon-alpha production |
| negative regulation of cytokine biosynthetic process |
| receptor signaling pathway via JAK-STAT |
| receptor signaling pathway via STAT |
| negative regulation of type I interferon production |
| regulation of interferon-beta production |
| negative regulation of innate immune response |
| interferon-gamma-mediated signaling pathway |
| transcription coregulator activity |
| negative regulation of response to biotic stimulus |
| regulation of cytokine biosynthetic process |
| positive regulation of protein ubiquitination |
| regulation of type I interferon production |
| positive regulation of protein modification by small protein conjugation or removal |
| negative regulation of immune response |
| cellular response to interferon-gamma |
| response to interferon-gamma |
| regulation of protein ubiquitination |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cytokine production |
| negative regulation of response to external stimulus |
| negative regulation of immune system process |
| regulation of innate immune response |
| transcription by RNA polymerase II |
| inflammatory response |
| regulation of response to biotic stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| defense response to other organism |
| cellular response to cytokine stimulus |
| identical protein binding |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| regulation of immune response |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| regulation of immune system process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| regulation of protein modification process |
| immune response |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17731
- Expression level (log2 read counts): 5.2
Expression Distribution
NMI Expression in NALM6 Cells: 5.2
