NSUN5

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. {ECO:0000305|PubMed:23913415}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	-2.84
LY2090314 0.003μM R08 exp500 no dilution day6	-2.14
PU-H71 1μM R08 exp515	-1.79
PFI-2 4μM R05 exp239	-1.76
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.82
Cyclosporin-A 3μM R07 exp348	1.92
BN82002 4μM R07 exp340	1.95
VHL-ligand-1 20μM R07 exp421	1.98
5-Azacytidine 2μM R07 exp330	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution