NUPR1

Gene Information

Official Symbol: NUPR1
Official Name: nuclear protein 1, transcriptional regulator
Aliases and Previous Symbols: N/A
Entrez ID: 26471
UniProt: O60356
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. {ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377}.

Pfam Domains GO Terms

Pfam Domains

Phospho p8

GO Terms

negative regulation of type B pancreatic cell proliferation

acetyltransferase activator activity

positive regulation of oxidative phosphorylation

regulation of type B pancreatic cell proliferation

negative regulation of autophagosome assembly

regulation of female gonad development

negative regulation of programmed necrotic cell death

negative regulation of glycolytic process

positive regulation of neuroinflammatory response

negative regulation of necrotic cell death

negative regulation of purine nucleotide metabolic process

negative regulation of nucleotide metabolic process

regulation of gonad development

regulation of programmed necrotic cell death

negative regulation of cardiac muscle cell apoptotic process

negative regulation of ATP metabolic process

negative regulation of striated muscle cell apoptotic process

negative regulation of fibroblast proliferation

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of necrotic cell death

regulation of oxidative phosphorylation

regulation of neuroinflammatory response

negative regulation of macroautophagy

regulation of autophagosome assembly

regulation of cardiac muscle cell apoptotic process

negative regulation of muscle cell apoptotic process

negative regulation of organelle assembly

regulation of striated muscle cell apoptotic process

negative regulation of epithelial cell apoptotic process

negative regulation of cellular carbohydrate metabolic process

regulation of vacuole organization

protein-DNA complex

positive regulation of ATP metabolic process

negative regulation of carbohydrate metabolic process

intrinsic apoptotic signaling pathway by p53 class mediator

skeletal muscle cell differentiation

positive regulation of neuron apoptotic process

positive regulation of intrinsic apoptotic signaling pathway

regulation of muscle cell apoptotic process

acute inflammatory response

intrinsic apoptotic signaling pathway in response to DNA damage

regulation of epithelial cell apoptotic process

regulation of glycolytic process

regulation of fibroblast proliferation

negative regulation of autophagy

regulation of response to endoplasmic reticulum stress

regulation of carbohydrate catabolic process

negative regulation of small molecule metabolic process

positive regulation of neuron death

positive regulation of proteasomal protein catabolic process

regulation of purine nucleotide metabolic process

regulation of nucleotide metabolic process

signal transduction by p53 class mediator

regulation of ATP metabolic process

positive regulation of proteolysis involved in cellular protein catabolic process

skeletal muscle tissue development

negative regulation of epithelial cell proliferation

skeletal muscle organ development

male gonad development

development of primary male sexual characteristics

regulation of cellular carbohydrate metabolic process

positive regulation of inflammatory response

positive regulation of cellular protein catabolic process

protein acetylation

intrinsic apoptotic signaling pathway

male sex differentiation

regulation of generation of precursor metabolites and energy

regulation of reproductive process

regulation of intrinsic apoptotic signaling pathway

negative regulation of DNA-binding transcription factor activity

regulation of macroautophagy

positive regulation of apoptotic signaling pathway

regulation of proteasomal protein catabolic process

protein acylation

regulation of carbohydrate metabolic process

regulation of neuron apoptotic process

gonad development

regulation of proteolysis involved in cellular protein catabolic process

development of primary sexual characteristics

positive regulation of protein catabolic process

regulation of organelle assembly

regulation of cellular protein catabolic process

negative regulation of cellular catabolic process

sex differentiation

striated muscle tissue development

transcription coactivator activity

apoptotic signaling pathway

muscle organ development

muscle tissue development

negative regulation of catabolic process

regulation of neuron death

regulation of autophagy

regulation of epithelial cell proliferation

regulation of inflammatory response

positive regulation of proteolysis

positive regulation of cellular catabolic process

negative regulation of organelle organization

regulation of protein catabolic process

chromatin binding

regulation of apoptotic signaling pathway

reproductive structure development

regulation of small molecule metabolic process

regulation of DNA-binding transcription factor activity

reproductive system development

positive regulation of catabolic process

negative regulation of phosphorylation

positive regulation of defense response

muscle structure development

inflammatory response

response to toxic substance

cell population proliferation

negative regulation of phosphate metabolic process

negative regulation of phosphorus metabolic process

negative regulation of cell cycle

positive regulation of response to external stimulus

positive regulation of apoptotic process

positive regulation of programmed cell death

developmental process involved in reproduction

negative regulation of cell population proliferation

positive regulation of cell death

perinuclear region of cytoplasm

negative regulation of cellular component organization

regulation of proteolysis

regulation of cellular response to stress

regulation of defense response

cellular response to DNA damage stimulus

regulation of cellular catabolic process

negative regulation of apoptotic process

negative regulation of programmed cell death

apoptotic process

regulation of cellular component biogenesis

negative regulation of cell death

regulation of catabolic process

positive regulation of intracellular signal transduction

programmed cell death

positive regulation of phosphorylation

cell death

regulation of response to external stimulus

positive regulation of phosphate metabolic process

positive regulation of phosphorus metabolic process

negative regulation of molecular function

regulation of cell cycle

positive regulation of protein modification process

regulation of organelle organization

defense response

reproductive process

reproduction

positive regulation of catalytic activity

negative regulation of nucleobase-containing compound metabolic process

DNA binding

regulation of response to stress

regulation of apoptotic process

protein-containing complex assembly

regulation of programmed cell death

regulation of phosphorylation

positive regulation of cellular protein metabolic process

regulation of cell population proliferation

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

positive regulation of signal transduction

regulation of cell death

intracellular signal transduction

cellular response to stress

positive regulation of protein metabolic process

positive regulation of RNA metabolic process

tissue development

positive regulation of molecular function

regulation of phosphate metabolic process

regulation of phosphorus metabolic process

positive regulation of cell communication

positive regulation of signaling

regulation of intracellular signal transduction

regulation of protein modification process

protein-containing complex subunit organization

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
MKC9989 10μM R03 exp133	-2.16
GSK-J4 1-1.25μM to day4 R07 exp363	1.8
Latrunculin-B 10μM R07 exp374	2.02

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14909
Expression level (log2 read counts): 4.17

Expression Distribution