ODF1
Gene Information
- Official Symbol: ODF1
- Official Name: outer dense fiber of sperm tails 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4956
- UniProt: Q14990
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008].
- UniProt Summary: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10113
- Expression level (log2 read counts): -7.68
ODF1 Expression in NALM6 Cells: -7.68
