Entrez Summary: The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: May play some role in mitochondrial processes.
Pfam DomainsGO Terms
Pfam Domains
OPA3
GO Terms
mitochondrion morphogenesis
neuromuscular process
visual perception
sensory perception of light stimulus
regulation of lipid metabolic process
mitochondrion organization
cell part morphogenesis
regulation of growth
cellular component morphogenesis
sensory perception
mitochondrion
nervous system process
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)