OSTM1
Gene Information
- Official Symbol: OSTM1
- Official Name: osteoclastogenesis associated transmembrane protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 28962
- UniProt: Q86WC4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008].
- UniProt Summary: Required for osteoclast and melanocyte maturation and function. {ECO:0000250, ECO:0000269|PubMed:21527911}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7926
- Expression level (log2 read counts): 5.45
OSTM1 Expression in NALM6 Cells: 5.45
