PAX4
Gene Information
- Official Symbol: PAX4
- Official Name: paired box 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 5078
- UniProt: O43316
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4114
- Expression level (log2 read counts): -0.8
PAX4 Expression in NALM6 Cells: -0.8
