PDC
Gene Information
- Official Symbol: PDC
- Official Name: phosducin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5132
- UniProt: P20941
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
- UniProt Summary: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. {ECO:0000269|PubMed:10866677}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16412
- Expression level (log2 read counts): -2.96
PDC Expression in NALM6 Cells: -2.96
