PDE4D
Gene Information
- Official Symbol: PDE4D
- Official Name: phosphodiesterase 4D
- Aliases and Previous Symbols: N/A
- Entrez ID: 5144
- UniProt: Q08499
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PDEase I |
GO Terms
| adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate |
| adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate |
| negative regulation of relaxation of cardiac muscle |
| positive regulation of heart rate by epinephrine-norepinephrine |
| adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process |
| beta-2 adrenergic receptor binding |
| negative regulation of relaxation of muscle |
| positive regulation of blood pressure by epinephrine-norepinephrine |
| regulation of relaxation of cardiac muscle |
| regulation of heart rate by chemical signal |
| G protein-coupled receptor signaling pathway involved in heart process |
| 3,5-cyclic-nucleotide phosphodiesterase activity |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine |
| cAMP catabolic process |
| regulation of cell communication by electrical coupling involved in cardiac conduction |
| regulation of relaxation of muscle |
| 3,5-cyclic-AMP phosphodiesterase activity |
| regulation of cell communication by electrical coupling |
| positive regulation of interleukin-5 production |
| cellular response to epinephrine stimulus |
| cyclic nucleotide catabolic process |
| response to epinephrine |
| regulation of interleukin-5 production |
| cAMP metabolic process |
| cAMP binding |
| negative regulation of cAMP-mediated signaling |
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| adrenergic receptor signaling pathway |
| calcium channel complex |
| positive regulation of heart rate |
| negative regulation of heart contraction |
| regulation of ryanodine-sensitive calcium-release channel activity |
| negative regulation of peptidyl-serine phosphorylation |
| voltage-gated calcium channel complex |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| positive regulation of interleukin-2 production |
| establishment of endothelial barrier |
| purine ribonucleotide catabolic process |
| ribonucleotide catabolic process |
| negative regulation of blood circulation |
| positive regulation of blood pressure |
| regulation of cardiac muscle cell contraction |
| positive regulation of heart contraction |
| cyclic nucleotide metabolic process |
| regulation of actin filament-based movement |
| purine nucleotide catabolic process |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| regulation of cAMP-mediated signaling |
| endothelial cell development |
| smooth muscle contraction |
| purine-containing compound catabolic process |
| regulation of interleukin-2 production |
| drug binding |
| scaffold protein binding |
| positive regulation of interferon-gamma production |
| nucleotide catabolic process |
| regulation of cardiac conduction |
| positive regulation of blood circulation |
| nucleoside phosphate catabolic process |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| ATPase binding |
| endothelial cell differentiation |
| multicellular organism growth |
| neutrophil chemotaxis |
| regulation of calcium ion transmembrane transporter activity |
| granulocyte chemotaxis |
| regulation of striated muscle contraction |
| neutrophil migration |
| regulation of systemic arterial blood pressure |
| endothelium development |
| regulation of heart rate |
| regulation of calcium-mediated signaling |
| regulation of interferon-gamma production |
| regulation of calcium ion transport into cytosol |
| granulocyte migration |
| heart process |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to monoamine |
| response to catecholamine |
| nucleobase-containing small molecule biosynthetic process |
| regulation of sequestering of calcium ion |
| ion channel binding |
| organophosphate catabolic process |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| myeloid leukocyte migration |
| regulation of peptidyl-serine phosphorylation |
| leukocyte chemotaxis |
| cAMP-mediated signaling |
| regulation of calcium ion transmembrane transport |
| regulation of muscle contraction |
| regulation of cation channel activity |
| cyclic-nucleotide-mediated signaling |
| regulation of signaling receptor activity |
| T cell receptor signaling pathway |
| regulation of blood pressure |
| cellular response to lipopolysaccharide |
| carbohydrate derivative catabolic process |
| cellular response to molecule of bacterial origin |
| epithelial cell development |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| cell chemotaxis |
| cellular response to biotic stimulus |
| regulation of muscle system process |
| nuclear membrane |
| regulation of heart contraction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| muscle contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| aging |
| regulation of blood circulation |
| antigen receptor-mediated signaling pathway |
| muscle system process |
| purine ribonucleotide metabolic process |
| response to lipopolysaccharide |
| apical plasma membrane |
| response to molecule of bacterial origin |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| regulation of cation transmembrane transport |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| enzyme binding |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| leukocyte migration |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| developmental growth |
| blood circulation |
| growth |
| circulatory system process |
| negative regulation of protein phosphorylation |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| negative regulation of phosphorylation |
| nucleotide metabolic process |
| positive regulation of cytokine production |
| immune response-activating cell surface receptor signaling pathway |
| nucleoside phosphate metabolic process |
| regulation of ion transmembrane transport |
| organic cyclic compound catabolic process |
| immune response-regulating cell surface receptor signaling pathway |
| centrosome |
| negative regulation of intracellular signal transduction |
| cellular response to lipid |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| chemotaxis |
| taxis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| small molecule biosynthetic process |
| regulation of system process |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| activation of immune response |
| cellular response to nitrogen compound |
| epithelial cell differentiation |
| response to bacterium |
| regulation of cytokine production |
| regulation of ion transport |
| response to lipid |
| positive regulation of immune response |
| organophosphate metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell migration |
| regulation of cellular component movement |
| response to organonitrogen compound |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| epithelium development |
| positive regulation of immune system process |
| regulation of immune response |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| EPZ-5676 30μM R05 exp233 | -2.13 |
| CFI-400945 25μM R08 exp469 | -1.9 |
| Mubritinib 0.2μM R01 exp48 | -1.85 |
| LB-100 2μM R05 exp210 | -1.79 |
| Sulforaphane 9μM R08 exp525 | -1.75 |
| Lenalidomide 20μM R07 exp375 | 1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18652
- Expression level (log2 read counts): 4.02
Expression Distribution
PDE4D Expression in NALM6 Cells: 4.02
