PGAP2
Gene Information
- Official Symbol: PGAP2
- Official Name: post-GPI attachment to proteins 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 27315
- UniProt: Q9UHJ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene plays a role in the maturation of glycosylphosphatidylinositol (GPI) anchors on GPI-anchored proteins. Mutations in this gene are associated with an autosomal recessive syndrome characterized by hyperphosphatasia and intellectual disability. [provided by RefSeq, Jul 2017].
- UniProt Summary: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11797
- Expression level (log2 read counts): 4.65
PGAP2 Expression in NALM6 Cells: 4.65
