PHYKPL
Gene Information
- Official Symbol: PHYKPL
- Official Name: 5-phosphohydroxy-L-lysine phospho-lyase
- Aliases and Previous Symbols: N/A
- Entrez ID: 85007
- UniProt: Q8IUZ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
- UniProt Summary: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. {ECO:0000269|PubMed:22241472}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9241
- Expression level (log2 read counts): 5.55
PHYKPL Expression in NALM6 Cells: 5.55
