PI16
Gene Information
- Official Symbol: PI16
- Official Name: peptidase inhibitor 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 221476
- UniProt: Q6UXB8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May inhibit cardiomyocyte growth. {ECO:0000250|UniProtKB:Q9ET66}.
Pfam Domains GO Terms
Pfam Domains
| CAP |
GO Terms
| negative regulation of cell growth involved in cardiac muscle cell development |
| peptidase inhibitor activity |
| negative regulation of cardiac muscle cell differentiation |
| regulation of cell growth involved in cardiac muscle cell development |
| negative regulation of cardiocyte differentiation |
| negative regulation of heart growth |
| negative regulation of cardiac muscle tissue growth |
| negative regulation of cardiac muscle hypertrophy |
| negative regulation of muscle hypertrophy |
| negative regulation of organ growth |
| negative regulation of cardiac muscle tissue development |
| regulation of cardiac muscle cell differentiation |
| negative regulation of striated muscle cell differentiation |
| negative regulation of striated muscle tissue development |
| negative regulation of muscle organ development |
| regulation of cardiocyte differentiation |
| negative regulation of muscle tissue development |
| negative regulation of muscle cell differentiation |
| regulation of cardiac muscle hypertrophy |
| regulation of cardiac muscle tissue growth |
| regulation of muscle hypertrophy |
| regulation of heart growth |
| regulation of cardiac muscle tissue development |
| regulation of muscle adaptation |
| regulation of organ growth |
| regulation of striated muscle cell differentiation |
| negative regulation of developmental growth |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of muscle cell differentiation |
| negative regulation of cell growth |
| regulation of muscle system process |
| negative regulation of growth |
| negative regulation of peptidase activity |
| regulation of developmental growth |
| negative regulation of cell development |
| negative regulation of proteolysis |
| regulation of cell growth |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| regulation of system process |
| regulation of growth |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| regulation of cell development |
| negative regulation of developmental process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| regulation of hydrolase activity |
| extracellular space |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SNS-032 15μM R08 exp443 | -2.2 |
| NFN1 0.4μM R03 exp99 | -1.75 |
| Rapamycin 2μM R07 exp306 | 2.03 |
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | 2.1 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5618
- Expression level (log2 read counts): -0.09
Expression Distribution
PI16 Expression in NALM6 Cells: -0.09
