PI4KA
Gene Information
- Official Symbol: PI4KA
- Official Name: phosphatidylinositol 4-kinase alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5297
- UniProt: P42356
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014].
- UniProt Summary: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1138
- Expression level (log2 read counts): 8.08
PI4KA Expression in NALM6 Cells: 8.08
