PMS1
Gene Information
- Official Symbol: PMS1
- Official Name: PMS1 homolog 1, mismatch repair system component
- Aliases and Previous Symbols: N/A
- Entrez ID: 5378
- UniProt: P54277
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probably involved in the repair of mismatches in DNA. {ECO:0000269|PubMed:10748105}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18967
- Expression level (log2 read counts): 6.02
PMS1 Expression in NALM6 Cells: 6.02
