POLE3
Gene Information
- Official Symbol: POLE3
- Official Name: DNA polymerase epsilon 3, accessory subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 54107
- UniProt: Q9NRF9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
Pfam Domains GO Terms
Pfam Domains
| CBFD NFYB HMF |
GO Terms
| heterochromatin assembly involved in chromatin silencing |
| heterochromatin organization involved in chromatin silencing |
| nucleosome mobilization |
| epsilon DNA polymerase complex |
| heterochromatin assembly |
| heterochromatin organization |
| Ada2/Gcn5/Ada3 transcription activator complex |
| telomere maintenance via semi-conservative replication |
| DNA-directed DNA polymerase activity |
| cellular response to gamma radiation |
| CENP-A containing nucleosome assembly |
| CENP-A containing chromatin organization |
| DNA replication initiation |
| chromatin remodeling at centromere |
| centromere complex assembly |
| DNA replication-independent nucleosome assembly |
| DNA replication-independent nucleosome organization |
| nuclear DNA replication |
| cell cycle DNA replication |
| histone H3 acetylation |
| histone exchange |
| histone acetyltransferase activity |
| response to gamma radiation |
| chromatin organization involved in negative regulation of transcription |
| chromatin silencing |
| cellular response to ionizing radiation |
| chromatin organization involved in regulation of transcription |
| ATP-dependent chromatin remodeling |
| negative regulation of gene expression, epigenetic |
| telomere maintenance |
| telomere organization |
| DNA biosynthetic process |
| histone acetylation |
| nucleosome assembly |
| internal peptidyl-lysine acetylation |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| DNA-dependent DNA replication |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| chromatin assembly |
| protein acetylation |
| response to ionizing radiation |
| gene silencing |
| chromatin assembly or disassembly |
| nucleosome organization |
| chromatin remodeling |
| cellular response to radiation |
| DNA packaging |
| protein acylation |
| protein-DNA complex assembly |
| DNA replication |
| regulation of gene expression, epigenetic |
| protein-DNA complex subunit organization |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| DNA conformation change |
| peptidyl-lysine modification |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| anatomical structure homeostasis |
| histone modification |
| covalent chromatin modification |
| response to radiation |
| protein heterodimerization activity |
| mitotic cell cycle process |
| mitotic cell cycle |
| chromatin organization |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| cellular protein-containing complex assembly |
| peptidyl-amino acid modification |
| cellular homeostasis |
| cell cycle process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 38/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 2/25 |
| breast | 2/33 |
| central nervous system | 3/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 1/1 |
| gastric | 1/15 |
| kidney | 6/21 |
| liver | 1/20 |
| lung | 2/75 |
| lymphocyte | 1/14 |
| ovary | 1/26 |
| pancreas | 1/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1189
- Expression level (log2 read counts): 7.32
Expression Distribution
POLE3 Expression in NALM6 Cells: 7.32
